Cytotoxic Polyhydroxy-Isoprenoids from Neodidymelliopsis negundinis .
Patcharee PripdeevechSarunpron KhruengsaiChutima TanapichatsakulWael M AfifiWinnie Chemutai SumKevin D HydeSherif Saeed EbadaPublished in: Journal of natural products (2024)
Fungal-derived natural products continue to play a pivotal role in the discovery of drug agents for human, veterinary, and general agricultural use. The fungus Neodidymelliopsis negundinis presents a significant saprobic ascomycete whose metabolites remained hitherto unstudied. Herein we report the isolation of eight unprecedented secondary metabolites named neodidymelliosides A and B ( 1 and 2 ), neodidymelliol A ( 3 ), and neodidymellioic acids A-E ( 4 - 8 ) produced by the submerged cultures of the fungus. Compound 1 proved to be the most active compound, with IC 50 values ranging between 4.8 and 8.8 μM against KB3.1 (cervix), PC-3 (prostate), MCF-7 (breast), SKOV-3 (ovary), A431 (skin), and A549 (lung) cell lines. Compound 1 revealed significant inhibition of Staphylococcus aureus and Candida albicans biofilms.
Keyphrases
- candida albicans
- biofilm formation
- staphylococcus aureus
- ms ms
- endothelial cells
- prostate cancer
- small molecule
- risk assessment
- single cell
- emergency department
- preterm birth
- escherichia coli
- pluripotent stem cells
- breast cancer cells
- pseudomonas aeruginosa
- methicillin resistant staphylococcus aureus
- anti inflammatory