BMI1 promotes cholangiocarcinoma progression and correlates with antitumor immunity in an exosome-dependent manner.

Zengli LiuChunxiao HuLijie ZhengJialiang LiuKangshuai LiXingyong LiYue WangWentao MuTianli ChenAnda ShiBo QiuXin ZhangZong-Li ZhangYunfei Xu

Published in: Cellular and molecular life sciences : CMLS (2022)

BMI1 is an unfavorable prognostic biomarker of CCA. Our data depict a novel function of BMI1 in CCA tumorigenesis and metastasis mediated by exosomes. Besides, BMI1 inhibition may augment immune checkpoint blockade to inhibit tumor progression by activating cell-intrinsic immunity of CCA.

Keyphrases

body mass index
weight gain
stem cells
single cell
poor prognosis
electronic health record
cell therapy
big data
bone marrow
long non coding rna