Lipopolysaccharide from Rhodobacter sphaeroides (TLR4 antagonist) attenuates hypersensitivity and modulates nociceptive factors.

Agnieszka M Jurga Ewelina Rojewska Wioletta Makuch Joanna Mika

Published in: Pharmaceutical biology (2018)

Our results provide evidence that LPS-RSU influences pain through the expression of TLR4. TLR4 blockade has analgesic properties and restores the balance between nociceptive factors, which indicates its engagement in neuropathy development.

Keyphrases

inflammatory response
toll like receptor
neuropathic pain
immune response
lps induced
nuclear factor
spinal cord
poor prognosis
chronic pain
anti inflammatory
spinal cord injury
pain management
social media
drug induced
binding protein