Intermittent Fasting Resolves Dyslipidemia and Atherogenesis in Apolipoprotein E-Deficient Mice in a Diet-Dependent Manner, Irrespective of Sex.
Jules MérianLamia GhezaliCharlotte TrenteseauxThibaut DuparcDiane BeuzelinVanessa BouguetochGuillaume CombesNabil SioufiLaurent O MartinezSouad NajibPublished in: Cells (2023)
In humans and animal models, intermittent fasting (IF) interventions promote body weight loss, improve metabolic health, and are thought to lower cardiovascular disease risk. However, there is a paucity of reports on the relevance of such nutritional interventions in the context of dyslipidemia and atherosclerotic cardiovascular diseases. The present study assessed the metabolic and atheroprotective effects of intermittent fasting intervention (IF) in atherosclerosis-prone apolipoprotein E-deficient ( Apoe -/- ) mice. Groups of male and female Apoe -/- mice were fed a regular (chow) or atherogenic (high-fat, high-cholesterol, HFCD) diet for 4 months, either ad libitum or in an alternate-day fasting manner. The results show that IF intervention improved glucose and lipid metabolism independently of sex. However, IF only decreased body weight gain in males fed chow diet and differentially modulated adipose tissue parameters and liver steatosis in a diet composition-dependent manner. Finally, IF prevented spontaneous aortic atherosclerotic lesion formation in mice fed chow diet, irrespective of sex, but failed to reduce HFCD-diet-induced atherosclerosis. Overall, the current work indicates that IF interventions can efficiently improve glucose homeostasis and treat atherogenic dyslipidemia, but a degree of caution is warranted with regard to the individual sex and the composition of the dietary regimen.
Keyphrases
- weight loss
- physical activity
- cardiovascular disease
- blood glucose
- insulin resistance
- weight gain
- high fat diet induced
- bariatric surgery
- adipose tissue
- high fat diet
- roux en y gastric bypass
- randomized controlled trial
- glycemic control
- gastric bypass
- high intensity
- body mass index
- public health
- cognitive decline
- type diabetes
- metabolic syndrome
- mental health
- low density lipoprotein
- birth weight
- heart failure
- aortic valve
- wild type
- coronary artery
- pulmonary artery
- left ventricular
- pulmonary arterial hypertension
- obese patients
- climate change
- coronary artery disease
- mild cognitive impairment