Wnt, glucocorticoid and cellular prion protein cooperate to drive a mesenchymal phenotype with poor prognosis in colon cancer.

Sophie Mouillet-RichardAngélique GougeletBruno PassetCamille BrochardDelphine Le CorreCaterina Luana PitasiCamille JoubelMarine SroussiClaire GalloisJulien LavergneJohan CastilleMarthe VilotteNathalie Daniel-CarlierCamilla PilatiAurélien de ReynièsFatima DjouadiSabine ColnotThierry AndréJulien TaiebJean-Luc VilotteBéatrice RomagnoloPierre Laurent-Puig

Published in: Journal of translational medicine (2024)

-dependent vicious circle is pathognomonic of poor prognosis, mesenchymal CRC. Patients from this aggressive subtype of CRC may benefit from therapies targeting the PRNP-CTNNB1-NR3C1 axis.

Keyphrases

poor prognosis
long non coding rna
stem cells
end stage renal disease
bone marrow
chronic kidney disease
ejection fraction
newly diagnosed
prognostic factors
drug delivery
protein protein