Crucial Role of Lamin A/C in the Migration and Differentiation of MSCs in Bone.
Natividad Alcorta-SevillanoIratxe MacíasClara I RodríguezArantza InfantePublished in: Cells (2020)
Lamin A/C, intermediate filament proteins from the nuclear lamina encoded by the LMNA gene, play a central role in mediating the mechanosignaling of cytoskeletal forces into nucleus. In fact, this mechanotransduction process is essential to ensure the proper functioning of other tasks also mediated by lamin A/C: the structural support of the nucleus and the regulation of gene expression. In this way, lamin A/C is fundamental for the migration and differentiation of mesenchymal stem cells (MSCs), the progenitors of osteoblasts, thus affecting bone homeostasis. Bone formation is a complex process regulated by chemical and mechanical cues, coming from the surrounding extracellular matrix. MSCs respond to signals modulating the expression levels of lamin A/C, and therefore, adapting their nuclear shape and stiffness. To promote cell migration, MSCs need soft nuclei with low lamin A content. Conversely, during osteogenic differentiation, lamin A/C levels are known to be increased. Several LMNA mutations present a negative impact in the migration and osteogenesis of MSCs, affecting bone tissue homeostasis and leading to pathological conditions. This review aims to describe these concepts by discussing the latest state-of-the-art in this exciting area, focusing on the relationship between lamin A/C in MSCs' function and bone tissue from both, health and pathological points of view.
Keyphrases
- mesenchymal stem cells
- umbilical cord
- gene expression
- bone mineral density
- bone marrow
- extracellular matrix
- cell migration
- healthcare
- soft tissue
- cell therapy
- bone regeneration
- bone loss
- poor prognosis
- dna methylation
- postmenopausal women
- climate change
- health information
- muscular dystrophy
- mental health
- social media
- long non coding rna