Similarities and differences in the localization, trafficking, and function of P-glycoprotein in MDR1-EGFP-transduced rat versus human brain capillary endothelial cell lines.

Birthe GerickeSaskia BorsdorfInka WienbökerAndreas NoackSandra NoackWolfgang Löscher

Published in: Fluids and barriers of the CNS (2021)

The present data indicate that MDR1-EGFP transduced RBE4 cells are an interesting tool to study the biogenesis of lysosomes and Pgp-mediated lysosomal drug trapping in response to chemotherapeutic agents and other compounds at the level of the blood-brain barrier.

Keyphrases

multidrug resistant
induced apoptosis
cell cycle arrest
oxidative stress
endothelial cells
electronic health record
big data
emergency department
cell death
signaling pathway
endoplasmic reticulum stress
artificial intelligence
deep learning