HMG co-reductase expression and response to intravesical Bacillus Calmette-Guérin in patients with high grade non-muscle invasive urinary bladder cancer receiving statins.

Jamie V KrishnanAndrew SymingtonNeil KernohanSuan BrayAllison RobertsonGhulam Nabi

Published in: Scottish medical journal (2023)

This study showed a differential expression of HMGCR in responders vs. non-responders to BCG for high-risk NMIBC on statins. This data should form the basis of a further research and multi-centre study in a larger cohort, using HMGCR as a biomarker of response in patients on statins.

Keyphrases

high grade
cardiovascular disease
muscle invasive bladder cancer
end stage renal disease
newly diagnosed
poor prognosis
ejection fraction
peritoneal dialysis
prognostic factors
patient reported outcomes
binding protein