Effect of CES1 genetic variation on enalapril steady-state pharmacokinetics and pharmacodynamics in healthy subjects.
Lucy H HerXinwen WangJian ShiHee Jae ChoiSun Min JungLogan S SmithAudrey H WuBarry E BleskeHao-Jie ZhuPublished in: British journal of clinical pharmacology (2021)
The CES1 loss-of-function G143E variant significantly impaired enalapril activation and its systolic blood pressure-lowering effect in healthy volunteers.