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Effect of CES1 genetic variation on enalapril steady-state pharmacokinetics and pharmacodynamics in healthy subjects.

Lucy H HerXinwen WangJian ShiHee Jae ChoiSun Min JungLogan S SmithAudrey H WuBarry E BleskeHao-Jie Zhu
Published in: British journal of clinical pharmacology (2021)
The CES1 loss-of-function G143E variant significantly impaired enalapril activation and its systolic blood pressure-lowering effect in healthy volunteers.
Keyphrases
  • blood pressure
  • hypertensive patients
  • heart rate
  • heart failure
  • left ventricular