Impact of short-term discontinuation of ivermectin-based chemoprevention on onchocerciasis transmission in endemic settings with long history of mass drug administration.

Arnauld Efon-EkangouoHugues Clotaire Nana-DjeungaNarcisse Nzune-TocheRaïssa Dongmo-YemeleJean BopdaViviane OngbassombenLaurentine SumoAnne GeigerThomas B NutmanJoseph Kamgno

Published in: PLoS neglected tropical diseases (2023)

The continued decline in prevalence and CMFL observed ~2 years after MDA disruption is consistent with mathematical predictions (ONCHOSIM) and shows that additional efforts and resources are not needed to mitigate the effects of short-term MDA disruption in highly endemic settings prior to intervention with long treatment histories.

Keyphrases

drug administration
breast cancer cells
randomized controlled trial
risk factors
cell proliferation
signaling pathway
smoking cessation