Utilizing biologic disease-modifying anti-rheumatic treatment sequences to subphenotype rheumatoid arthritis.
Priyam DasDana WeisenfeldKumar DahalDebsurya DeVivi FeathersJonathan S CoblynMichael E WeinblattNancy A ShadickTianxi CaiKatherine P LiaoPublished in: Arthritis research & therapy (2023)
We observed that RA subjects can be clustered based on the sequence of b/tsDMARD prescriptions over time and that the clusters were correlated with differing trajectories of disease activity over time. This study highlights an alternative approach to consider subphenotyping of patients with RA for studies aimed at understanding treatment response.