Mechanism and Role of the Neuropeptide LGI1 Receptor ADAM23 in Regulating Biomarkers of Ferroptosis and Progression of Esophageal Cancer.

Chen ChenJun Zhao Jing-Ni Liu Chenyu Sun

Published in: Disease markers (2021)

The study showed that the lncRNA, ARHGEF26-AS1 acts as a miR-372-3p sponge that regulates the neuropeptide LGI1 receptor ADAM23 expression. This in turn not only inhibits the proliferation and migration of ESCC cells but also upregulates the ferroptosis pathway. A neuropeptide-related ferroptosis regulatory pathway was identified in this study.

Keyphrases

cell death
induced apoptosis
poor prognosis
cell cycle arrest
sensitive detection
long noncoding rna