Calcium and vitamin D supplementation and increased risk of serrated polyps: results from a randomised clinical trial.

Seth D CrockettElizabeth L BarryLeila A MottDennis J AhnenDouglas J RobertsonJoseph C AndersonKristen WallaceCarol A BurkeRobert S BresalierJane C FigueiredoDale C SnoverJohn A Baron

Published in: Gut (2018)

In a large multicentre chemoprevention study, we found evidence that calcium and vitamin D supplementation increased the risk of SSA/Ps. This appeared to be a late effect: 6-10 years after supplementation began. These possible risks must be weighed against the benefits of calcium and vitamin D supplementation. : Trial registration NUMBER: NCT00153816; Results.

Keyphrases

clinical trial
study protocol
phase ii
double blind
open label
phase iii
randomized controlled trial
placebo controlled
risk assessment