Effects of N-Acetylcysteine Supplementation on Oxidative Stress and Expression of Apoptosis-Related Genes in Testicular Tissue of Rats Exposed to Lead.

Fahimeh Abedini Bajgiran Zeinab Khazaei Koohpar Ali Salehzadeh

Published in: Biological trace element research (2022)

Lead exposure strongly motivated testicular cells towards apoptosis, caused an oxidant/antioxidant imbalance, and decreased sperm quality along with morphological changes in testis cells. NAC treatments was associated with protective effects on testicular tissue mainly by rebalancing of the antioxidants capacity, as well as downregulation of apoptosis-related genes.

Keyphrases

cell cycle arrest
oxidative stress
induced apoptosis
endoplasmic reticulum stress
cell death
pi k akt
germ cell
signaling pathway
cell proliferation
ischemia reperfusion injury
diabetic rats
dna damage
transcription factor
poor prognosis
anti inflammatory
heat shock