Acute thalamic damage as a prognostic biomarker for post-traumatic epileptogenesis.
Eppu ManninenKarthik CharyNiina LapinlampiPedro AndradeTomi PaananenAlejandra SierraJussi TohkaOlli GröhnAsla PitkänenPublished in: Epilepsia (2021)
An MRI parameter set reporting on acute and subacute neuropathologic changes common to experimental and human TBI presents a diagnostic biomarker for post-traumatic epileptogenesis. Significant enrichment of the study population was achieved even when using a single time-point measurement, producing an expected epilepsy rate of 73%.
Keyphrases
- liver failure
- respiratory failure
- endothelial cells
- traumatic brain injury
- drug induced
- aortic dissection
- temporal lobe epilepsy
- magnetic resonance imaging
- hepatitis b virus
- oxidative stress
- contrast enhanced
- deep brain stimulation
- computed tomography
- diffusion weighted imaging
- magnetic resonance
- pluripotent stem cells
- intensive care unit
- mechanical ventilation