Exercise training reduces oxidative stress in people living with HIV/AIDS: a pilot study.
Luís Fernando DereszCinthia Maria SchölerPaulo Ivo Homem Júnior de BittencourtMarlus KarstenMaria Letícia Rodrigues IkedaAnelise SonzaPedro Dal LagoPublished in: HIV clinical trials (2018)
Data-pooled analysis showed a decrease in GSSG/GSH and TBARS after the training period: log GSSG/GSH= -1.26 ± 0.57 versus -1.54 ± 0.65, p = .01 and log TBARS =0.73 ± 0.35 versus 0.43 ± 0.21, p = .01. This was paralleled by a rise in peak oxygen uptake (VO2peak = 29.14 ± 5.34 versus 32.48 ± 5.75 ml kg-1 min-1, p = .04). All the subjects who performed resistance exercises showed an average gain of 37 ± 8% in muscle strength with no difference between performing single or multiple sets in terms of muscle strength gain. The results reinforce the clinical importance of exercise as a rehabilitation intervention for PLWHA and emphasizes the safety of exercise at the physiological level with the potential to mediate health outcomes.
Keyphrases
- oxidative stress
- high intensity
- randomized controlled trial
- resistance training
- physical activity
- skeletal muscle
- dna damage
- electronic health record
- fluorescent probe
- machine learning
- big data
- antiretroviral therapy
- body composition
- risk assessment
- climate change
- artificial intelligence
- endoplasmic reticulum stress