Engineering CAR-NK cells to secrete IL-15 sustains their anti-AML functionality but is associated with systemic toxicities.
Ilias ChristodoulouWon Jin HoAndrew MarpleJonas W RavichAda TamRuyan RahnamaAdam FearnowCambrynne RietbergSean YanikElena E SolomouRavi VaradhanMichael A KoldobskiyChallice L BonifantPublished in: Journal for immunotherapy of cancer (2022)
Transgenic expression of CD123-CARs and sIL-15 enabled NK cells to function in the setting of chronic antigen exposure but was associated with systemic toxicities. Thus, our study provides the impetus to explore inducible and controllable expression systems to provide cytokine signals to AML-specific CAR-NK cells before embarking on early-phase clinical testing.