Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion.
Maximillian A RogersJoshua D HutchesonTakehito OkuiClaudia GoettschSasha A SinghArda HaluFlorian SchlotterHideyuki HigashiLixiang WangMary C WhelanAndrew K MlynarchikAlan DaughertyMasatoshi NomuraMasanori AikawaElena AikawaPublished in: Cardiovascular research (2022)
We propose a novel tethering function of DRP1 beyond its established fission function, with DRP1-mediated ER remodeling likely contributing to ER constriction of mitochondria that drives mitochondrial fission. We report that DRP1-driven remodeling of select ER micro-domains may critically regulate hepatic proteostasis and identify mdivi-1 as a novel small molecule PCSK9 inhibitor.