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Pharmacokinetics of caffeine self-administered in overdose in a Japanese patient admitted to hospital.

Koichiro AdachiSatoru BeppuMariko TerashimaToshiaki FukudaJun TomizawaMakiko ShimizuHiroshi Yamazaki
Published in: Journal of pharmaceutical health care and sciences (2021)
The patient underwent infusion with bicarbonate Ringer's solution and potassium chloride and was discharged on the third day of hospitalization despite taking a potentially lethal dose of caffeine. The virtual plasma exposures of caffeine estimated using the current simplified PBPK model were higher than the measured values. The present results based on drug monitoring data and additional pharmacokinetic predictions could serve as a useful guide in cases of caffeine overdose.
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