Hiroshi Yamazaki

ResearcherID Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 115

Top Venues

Xenobiotica; the fate of foreign compounds in biological systems

Drug metabolism and disposition: the biological fate of chemicals

Chemical research in toxicology

Journal of pharmaceutical health care and sciences

This page only lists publications with an associated author ORCID identifier.

Publications

Makiko Shimizu, Miaki Makiguchi, Yasuhiro Uno, Hiroshi Yamazaki
Quinuclidine N -Oxygenation Mediated by Flavin-Containing Monooxygenases 1 and 3 in Kidney and Liver Microsomes from Humans, Monkeys, Dogs, and Pigs. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Yasuhiro Uno, Kyoko Tsukiyama-Kohara, Mayumi Ishizuka, Hazuki Mizukawa, Norie Murayama, Hiroshi Yamazaki
Investigation of Functional Cytochrome P450 4A Enzymes in Liver and Kidney of Pigs, Cats, Tree Shrews, and Dogs in Comparison with the Metabolic Capacity of Human P450 4A11. Drug metabolism and disposition: the biological fate of chemicals 52 (9) (2024)
Shotaro Uehara, Norie Murayama, Yuichiro Higuchi, Makiko Shimizu, Hiroshi Suemizu, Frederick Peter Guengerich, Hiroshi Yamazaki
In Vivo and In Vitro Induction of Cytochrome P450 3A4 by Thalidomide in Humanized-Liver Mice and Experimental Human Hepatocyte HepaSH cells. Chemical research in toxicology (2024)
Shotaro Uehara, Norie Murayama, Yuichiro Higuchi, Makiko Shimizu, Hiroshi Suemizu, Frederick Peter Guengerich, Hiroshi Yamazaki
In Vivo and In Vitro Induction of Cytochrome P450 3A4 by Thalidomide in Humanized-Liver Mice and Experimental Human Hepatocyte HepaSH cells. Chemical research in toxicology 37 (5) (2024)
Makiko Shimizu, Miaki Makiguchi, Yasuhiro Uno, Hiroshi Yamazaki
Quinuclidine N -oxygenation mediated by flavin-containing monooxygenase (FMO) 1 and FMO3 in kidney and liver microsomes from humans, monkeys, dogs, and pigs . Drug metabolism and disposition: the biological fate of chemicals (2024)
Genki Ushirozako, Norie Murayama, Kyoko Tsukiyama-Kohara, Hiroshi Yamazaki, Yasuhiro Uno
Novel Tree Shrew Cytochrome P450 2Ds (CYP2D8a and CYP2D8b) Are Functional Drug-Metabolizing Enzymes that Metabolize Bufuralol and Dextromethorphan. Drug metabolism and disposition: the biological fate of chemicals 52 (4) (2024)
Shotaro Uehara, Norie Murayama, Yuichiro Higuchi, Makiko Shimizu, Hiroshi Suemizu, Frederick Peter Guengerich, Hiroshi Yamazaki
In Vivo and In Vitro Induction of Cytochrome P450 3A4 by Thalidomide in Humanized-Liver Mice and Experimental Human Hepatocyte HepaSH cells. Chemical research in toxicology 37 (5) (2024)
Koichiro Adachi, Maki Murata, Akiyoshi Inada, Takeyori Morimoto, Makiko Shimizu, Satoru Beppu, Hiroshi Yamazaki
Interaction of a caffeine overdose with clinical doses of contraceptive ethinyl estradiol in a young woman. Acute medicine & surgery 11 (1) (2024)
Koichiro Adachi, Maki Murata, Akiyoshi Inada, Takeyori Morimoto, Makiko Shimizu, Satoru Beppu, Hiroshi Yamazaki
Interaction of a caffeine overdose with clinical doses of contraceptive ethinyl estradiol in a young woman. Acute medicine & surgery 11 (1) (2024)
Yasuhiro Uno, Kyoko Tsukiyama-Kohara, Mayumi Ishizuka, Hazuki Mizukawa, Norie Murayama, Hiroshi Yamazaki
Investigation of functional cytochrome P450 4A enzymes in liver and kidney of pigs, cats, tree shrews, and dogs in comparison with the metabolic capacity of human P450 4A11. Drug metabolism and disposition: the biological fate of chemicals (2024)
Makiko Shimizu, Miaki Makiguchi, Yasuhiro Uno, Hiroshi Yamazaki
Quinuclidine N -Oxygenation Mediated by Flavin-Containing Monooxygenases 1 and 3 in Kidney and Liver Microsomes from Humans, Monkeys, Dogs, and Pigs. Drug metabolism and disposition: the biological fate of chemicals 52 (8) (2024)
Yasuhiro Uno, Norie Murayama, Hiroshi Yamazaki
Novel Cytochrome P450 2C119 Enzymes in Cynomolgus and Rhesus Macaques Metabolize Progesterone, Diclofenac, and Omeprazole. Drug metabolism and disposition: the biological fate of chemicals 52 (3) (2024)
Genki Ushirozako, Norie Murayama, Kyoko Tsukiyama-Kohara, Hiroshi Yamazaki, Yasuhiro Uno
Novel Tree Shrew Cytochrome P450 2Ds (CYP2D8a and CYP2D8b) Are Functional Drug-Metabolizing Enzymes that Metabolize Bufuralol and Dextromethorphan. Drug metabolism and disposition: the biological fate of chemicals 52 (4) (2024)
Ayaka Kojima, Masayuki Nadai, Norie Murayama, Hiroshi Yamazaki, Miki Katoh
Effects of tyrosine kinase inhibitors used for the treatment of non-small cell lung carcinoma on cytochrome P450 2J2 activities. Xenobiotica; the fate of foreign compounds in biological systems (2024)
Yasuhiro Uno, Norie Murayama, Hiroshi Yamazaki
Novel Cytochrome P450 2C119 Enzymes in Cynomolgus and Rhesus Macaques Metabolize Progesterone, Diclofenac, and Omeprazole. Drug metabolism and disposition: the biological fate of chemicals 52 (3) (2024)
Genki Ushirozako, Norie Murayama, Kyoko Tsukiyama-Kohara, Hiroshi Yamazaki, Yasuhiro Uno
Novel tree shrew cytochrome P450 2Ds ( CYP2D8a and CYP2D8b ) are functional drug-metabolizing enzymes that metabolize bufuralol and dextromethorphan . Drug metabolism and disposition: the biological fate of chemicals (2024)
Ayaka Kojima, Masayuki Nadai, Norie Murayama, Hiroshi Yamazaki, Miki Katoh
Effects of tyrosine kinase inhibitors used for the treatment of non-small cell lung carcinoma on cytochrome P450 2J2 activities. Xenobiotica; the fate of foreign compounds in biological systems (2024)
Genki Ushirozako, Yutaro Noda, Norie Murayama, Hiroaki Kawaguchi, Kyoko Tsukiyama-Kohara, Hiroshi Yamazaki, Yasuhiro Uno
Newly Identified Tree Shrew Cytochrome P450 2A13 ( CYP2A13 ) is Expressed in Liver and Lung and Encodes a Functional Drug-Metabolizing Enzyme Similar to Dog CYP2A13 and Pig CYP2A19. Drug metabolism and disposition: the biological fate of chemicals (2023)
Miaki Makiguchi, Makiko Shimizu, Yuka Yokota, Erika Shimamura, Eiji Hishinuma, Sakae Saito, Masahiro Hiratsuka, Hiroshi Yamazaki
Variants of Flavin-containing Monooxygenase 3 (FMO3) Found in Subjects in an Updated Database of Genome Resources . Drug metabolism and disposition: the biological fate of chemicals (2023)
Genki Ushirozako, Norie Murayama, Kyoko Tsukiyama-Kohara, Hiroshi Yamazaki, Yasuhiro Uno
Tree shrew cytochrome P450 2E1 is a functional enzyme that metabolises chlorzoxazone and p -nitrophenol. Xenobiotica; the fate of foreign compounds in biological systems (2023)
Yasuhiro Uno, Yutaro Noda, Saho Morikuni, Norie Murayama, Hiroshi Yamazaki
Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs. Xenobiotica; the fate of foreign compounds in biological systems (2023)
Daisuke Negishi, Okimichi Mitsumatsu, Hiromi Mitsumatsu, Miaki Makiguchi, Makiko Shimizu, Hiroshi Yamazaki
Synovial fluid and plasma concentrations of tedizolid in patients with osteoarthritis infected with Staphylococcus aureus effectively determined with fluorescence detection. Journal of pharmaceutical health care and sciences 9 (1) (2023)
Yasuhiro Uno, Shotaro Uehara, Genki Ushirozako, Tatsunori Masatani, Hiroshi Yamazaki
Chronic Toxoplasma infection affects gene expression of drug-metabolizing enzymes in mouse liver. Xenobiotica; the fate of foreign compounds in biological systems (2023)
Haruna Nagayoshi, Norie Murayama, Vitchan Kim, Donghak Kim, Shigeo Takenaka, Hiroshi Yamazaki, Frederick Peter Guengerich, Tsutomu Shimada
Oxidation of Naringenin, Apigenin, and Genistein by Human Family 1 Cytochrome P450 Enzymes and Comparison of Interaction of Apigenin with Human P450 1B1.1 and Scutellaria P450 82D.1. Chemical research in toxicology (2023)
Yasuhiro Uno, Shotaro Uehara, Genki Ushirozako, Norie Murayama, Hiroshi Suemizu, Hiroshi Yamazaki
Cytochrome P450 1A2 and 2C Enzymes Autoinduced by Omeprazole in Dog Hepatocytes and Human HepaRG and HepaSH Cells Are Involved in Omeprazole 5-Hydroxylation and Sulfoxidation. Xenobiotica; the fate of foreign compounds in biological systems (2023)
Makiko Shimizu, Shotaro Uehara, Katsuhiro Ohyama, Haruka Nishimura, Yoichi Tanaka, Yoshiro Saito, Hiroshi Suemizu, Sayaka Yoshida, Hiroshi Yamazaki
Pharmacokinetic Models Scaled-up from Humanized-liver Mouse Data Can Account for Drug Monitoring Results of Atomoxetine and Its 4-Hydroxylated and N -Demethylated Metabolites i n Pediatric Patients Genotyped for Cytochrome P450 2D6 . Drug metabolism and disposition: the biological fate of chemicals (2023)
Michiaki Kojima, Kanami Machida, Sumie Cho, Daichi Watanabe, Hiroyuki Seki, Miyuki Shimoji, Ayuko Imaoka, Hiroshi Yamazaki, Frederick Peter Guengerich, Katsunori Nakamura, Koujirou Yamamoto, Takeshi Akiyoshi, Hisakazu Ohtani
The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro . Xenobiotica; the fate of foreign compounds in biological systems (2023)
Yasuhiro Uno, Norie Murayama, Hiroshi Yamazaki
Novel cytochrome P450 2C119 enzymes in cynomolgus and rhesus macaques metabolize progesterone, diclofenac, and omeprazole . Drug metabolism and disposition: the biological fate of chemicals (2023)
Yasuhiro Uno, Saho Morikuni, Mitsuya Shiraishi, Atsushi Asano, Norie Murayama, Hiroshi Yamazaki
Novel cytochrome P450 2C94 (CYP2C94) functionally metabolizes diclofenac and omeprazole in dogs. Drug metabolism and disposition: the biological fate of chemicals (2023)
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroaki Kato, Hiroshi Yamazaki, Hiroshi Suemizu
The Unique Human N10-Glucuronidated Metabolite Formation from Olanzapine in Chimeric NOG-TKm30 Mice with Humanized Livers . Drug metabolism and disposition: the biological fate of chemicals (2023)
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroaki Kato, Hiroshi Yamazaki, Hiroshi Suemizu
The Unique Human N10-Glucuronidated Metabolite Formation from Olanzapine in Chimeric NOG-TKm30 Mice with Humanized Livers . Drug metabolism and disposition: the biological fate of chemicals (2023)
Yasuhiro Uno, Saho Morikuni, Norie Murayama, Hiroshi Yamazaki
2-Oxidation, 3-methyl hydroxylation, and 6-hydroxylation of skatole, a contributor to the odour of boar-tainted pork meat, mediated by porcine liver microsomal cytochromes P450 1A2, 2A19, 2E1, and 3A22. Xenobiotica; the fate of foreign compounds in biological systems (2023)
Yasuhiro Uno, Yutaro Noda, Saho Morikuni, Norie Murayama, Hiroshi Yamazaki
Liver microsomal cytochrome P450 3A-dependent drug oxidation activities in individual dogs. Xenobiotica; the fate of foreign compounds in biological systems (2023)
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroaki Kato, Hiroshi Yamazaki, Hiroshi Suemizu
The Unique Human N10-Glucuronidated Metabolite Formation from Olanzapine in Chimeric NOG-TKm30 Mice with Humanized Livers. Drug metabolism and disposition: the biological fate of chemicals 51 (4) (2023)
Genki Ushirozako, Yutaro Noda, Norie Murayama, Hiroaki Kawaguchi, Kyoko Tsukiyama-Kohara, Hiroshi Yamazaki, Yasuhiro Uno
Newly Identified Tree Shrew Cytochrome P450 2A13 ( CYP2A13 ) is Expressed in Liver and Lung and Encodes a Functional Drug-Metabolizing Enzyme Similar to Dog CYP2A13 and Pig CYP2A19. Drug metabolism and disposition: the biological fate of chemicals (2023)
Yasuhiro Uno, Saho Morikuni, Mitsuya Shiraishi, Atsushi Asano, Norie Murayama, Hiroshi Yamazaki
Novel cytochrome P450 2C94 (CYP2C94) functionally metabolizes diclofenac and omeprazole in dogs. Drug metabolism and disposition: the biological fate of chemicals (2023)
Shotaro Uehara, Norie Murayama, Yuichiro Higuchi, Nao Yoneda, Hiroshi Yamazaki, Hiroshi Suemizu
Comparison of mouse and human cytochrome P450 mediated-drug metabolising activities in hepatic and extrahepatic microsomes. Xenobiotica; the fate of foreign compounds in biological systems 52 (3) (2022)
Daisuke Ogiya, Norie Murayama, Yusuke Kamiya, Rie Saito, Sawako Shiraiwa, Rikio Suzuki, Shinichiro Machida, Kei Tazume, Kiyoshi Ando, Hiroshi Yamazaki
Low cerebrospinal fluid-to-plasma ratios of orally administered lenalidomide mediated by its low cell membrane permeability in patients with hematologic malignancies. Annals of hematology 101 (9) (2022)
Hiroshi Yamazaki, Makiko Shimizu
Species specificity and selection of models for drug oxidations mediated by polymorphic human enzymes . Drug metabolism and disposition: the biological fate of chemicals (2022)
Yusuke Kamiya, Kentaro Handa, Tomonori Miura, Junya Ohori, Makiko Shimizu, Masato Kitajima, Fumiaki Shono, Kimito Funatsu, Hiroshi Yamazaki
Correction to "An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats". Chemical research in toxicology 35 (8) (2022)
Yasuhiro Uno, Genki Ushirozako, Shotaro Uehara, Norie Murayama, Yuki Fujiki, Hiroaki Kawaguchi, Kyoko Tsukiyama-Kohara, Hiroshi Yamazaki
Newly identified tree shrew cytochrome P450 2B6 (CYP2B6) and pig CYP2B6b are functional drug-metabolising enzymes. Xenobiotica; the fate of foreign compounds in biological systems 52 (7) (2022)
Daisuke Negishi, Okimichi Mitsumatsu, Takahiro Matsumura, Hiromi Mitsumatsu, Miaki Makiguchi, Makiko Shimizu, Hiroshi Yamazaki
Plasma and synovial fluid concentrations of linezolid in patients with knee osteoarthritis infected with Staphylococcus aureus. Journal of pharmaceutical health care and sciences 8 (1) (2022)
Yasuhiro Uno, Saho Morikuni, Mitsuya Shiraishi, Atsushi Asano, Hiroaki Kawaguchi, Norie Murayama, Hiroshi Yamazaki
A comprehensive analysis of six forms of cytochrome P450 2C (CYP2C) in pigs. Xenobiotica; the fate of foreign compounds in biological systems (2022)
Yasuhiro Uno, Shiori Jikuya, Yutaro Noda, Norie Murayama, Hiroshi Yamazaki
A Comprehensive Investigation of Dog Cytochromes P450 3A (CYP3A) Reveals A Functional Role of Newly Identified CYP3A98 in Small Intestine . Drug metabolism and disposition: the biological fate of chemicals (2022)
Yasuhiro Uno, Shotaro Uehara, Moe Ijiri, Hiroaki Kawaguchi, Atsushi Asano, Mitsuya Shiraishi, Kaito Banju, Norie Murayama, Hiroshi Yamazaki
Molecular and Functional Characterization of N -Acetyltransferases in Common Marmosets and Pigs. Drug metabolism and disposition: the biological fate of chemicals 50 (11) (2022)
Ayaka Kojima, Masayuki Nadai, Norie Murayama, Hiroshi Yamazaki, Miki Katoh
Effects of multi-kinase inhibitors on the activity of cytochrome P450 2J2. Xenobiotica; the fate of foreign compounds in biological systems 52 (7) (2022)
Yasuhiro Uno, Norie Murayama, Moe Ijiri, Hiroaki Kawaguchi, Osamu Yamato, Mitsuya Shiraishi, Atsushi Asano, Hiroki Teraoka, Hazuki Mizukawa, Shouta M M Nakayama, Yoshinori Ikenaka, Mayumi Ishizuka, Hiroshi Yamazaki
Cytochrome P450 2J Genes Are Expressed in Dogs, Cats, and Pigs, and Encode Functional Drug-Metabolizing Enzymes. Drug metabolism and disposition: the biological fate of chemicals 50 (11) (2022)
Tsutomu Shimada, Haruna Nagayoshi, Norie Murayama, Atsuki Sawai, Vitchan Kim, Donghak Kim, Hiroshi Yamazaki, Frederick Peter Guengerich, Shigeo Takenaka
Oxidation of 3'-methoxyflavone, 4'-methoxyflavone, and 3',4'-dimethoxyflavone and their derivatives having 5,7-dihydroxyl moieties by human cytochromes P450 1B1 and 2A13. Xenobiotica; the fate of foreign compounds in biological systems 52 (2) (2022)
Koichiro Adachi, Satoru Beppu, Mariko Terashima, Wataru Kobari, Makiko Shimizu, Hiroshi Yamazaki
Pharmacokinetic modeling of over-the-counter drug diphenhydramine self-administered in overdoses in Japanese patients admitted to hospital. Journal of pharmaceutical health care and sciences 7 (1) (2021)
Koichiro Adachi, Satoru Beppu, Kei Nishiyama, Makiko Shimizu, Hiroshi Yamazaki
Pharmacokinetics of duloxetine self-administered in overdose with quetiapine and other antipsychotic drugs in a Japanese patient admitted to hospital. Journal of pharmaceutical health care and sciences 7 (1) (2021)
Hiroshi Yamazaki, Makiko Shimizu, Takahiro Otani, Ami Mizugaki, Kanae Mure, Sadao Suzuki, Hideki Ishikawa
Effects of polymorphic cytochrome P450 2A6 genotypes on chemoprevention against colorectal tumors in single Japanese cohort using daily low-dose aspirin: insights into future personalized treatments. Journal of pharmaceutical health care and sciences 7 (1) (2021)
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroshi Yamazaki, Hiroshi Suemizu
UDP-glucuronosyltransferase 1A4-mediated N2-glucuronidation is the major metabolic pathway of lamotrigine in chimeric NOG-TKm30 mice with humanised-livers. Xenobiotica; the fate of foreign compounds in biological systems 51 (10) (2021)
Koichiro Adachi, Satoru Beppu, Mariko Terashima, Toshiaki Fukuda, Jun Tomizawa, Makiko Shimizu, Hiroshi Yamazaki
Pharmacokinetics of caffeine self-administered in overdose in a Japanese patient admitted to hospital. Journal of pharmaceutical health care and sciences 7 (1) (2021)
Haruna Nagayoshi, Norie Murayama, Shigeo Takenaka, Vitchan Kim, Donghak Kim, Masayuki Komori, Hiroshi Yamazaki, Frederick Peter Guengerich, Tsutomu Shimada
Roles of cytochrome P450 2A6 in the oxidation of flavone, 4'-hydroxyflavone, and 4'-, 3'-, and 2'-methoxyflavones by human liver microsomes. Xenobiotica; the fate of foreign compounds in biological systems 51 (9) (2021)
Yusuke Kamiya, Kentaro Handa, Tomonori Miura, Junya Ohori, Makiko Shimizu, Masato Kitajima, Fumiaki Shono, Kimito Funatsu, Hiroshi Yamazaki
An Updated In Silico Prediction Method for Volumes of Systemic Circulation of 323 Disparate Chemicals for Use in Physiologically Based Pharmacokinetic Models to Estimate Plasma and Tissue Concentrations after Oral Doses in Rats. Chemical research in toxicology 34 (10) (2021)
Yusuke Kamiya, Kentaro Handa, Tomonori Miura, Mayu Yanagi, Kazuki Shigeta, Shiori Hina, Makiko Shimizu, Masato Kitajima, Fumiaki Shono, Kimito Funatsu, Hiroshi Yamazaki
In Silico Prediction of Input Parameters for Simplified Physiologically Based Pharmacokinetic Models for Estimating Plasma, Liver, and Kidney Exposures in Rats after Oral Doses of 246 Disparate Chemicals. Chemical research in toxicology 34 (2) (2021)
Koichiro Adachi, Yuki Sugitani, Ryo Unita, Kosuke Yoshida, Satoru Beppu, Mariko Terashima, Masaya Fujii, Makiko Shimizu, Hiroshi Yamazaki
Pharmacokinetics of loxoprofen in a self-administered overdose in a Japanese patient admitted to hospital. Journal of pharmaceutical health care and sciences 7 (1) (2021)
Tomonori Miura, Yusuke Kamiya, Shotaro Uehara, Norie Murayama, Makiko Shimizu, Hiroshi Suemizu, Hiroshi Yamazaki
Hepatotoxicological potential of P-toluic acid in humanised-liver mice investigated using simplified physiologically based pharmacokinetic models. Xenobiotica; the fate of foreign compounds in biological systems 51 (6) (2021)
Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki, Hiroshi Suemizu
Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes. Xenobiotica; the fate of foreign compounds in biological systems 51 (5) (2021)
Shogo Matsumoto, Shotaro Uehara, Hidetaka Kamimura, Hiroshi Ikeda, Satoshi Maeda, Machiko Hattori, Megumi Nishiwaki, Kazuhiko Kato, Hiroshi Yamazaki
Human total clearance values and volumes of distribution of typical human cytochrome P450 2C9/19 substrates predicted by single-species allometric scaling using pharmacokinetic data sets from common marmosets genotyped for P450 2C19. Xenobiotica; the fate of foreign compounds in biological systems 51 (4) (2021)
Yasuhiro Uno, Shotaro Uehara, Norie Murayama, Hiroshi Yamazaki
Genetic variants of aldehyde oxidase (AOX) 1 in cynomolgus and rhesus macaques. Xenobiotica; the fate of foreign compounds in biological systems 51 (4) (2021)
Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki, Hiroshi Suemizu
Human Aldehyde Oxidase 1-Mediated Carbazeran Oxidation in Chimeric TK-NOG Mice Transplanted with Human Hepatocytes. Drug metabolism and disposition: the biological fate of chemicals 48 (7) (2020)
Tsutomu Shimada, Haruna Nagayoshi, Norie Murayama, Shigeo Takenaka, Jun Katahira, Vitchan Kim, Donghak Kim, Masayuki Komori, Hiroshi Yamazaki, Frederick Peter Guengerich
Liquid chromatography-tandem mass spectrometry analysis of oxidation of 2'-, 3'-, 4'- and 6-hydroxyflavanones by human cytochrome P450 enzymes. Xenobiotica; the fate of foreign compounds in biological systems 51 (2) (2020)
Haruna Nagayoshi, Norie Murayama, Masaki Tsujino, Shigeo Takenaka, Jun Katahira, Vitchan Kim, Donghak Kim, Masayuki Komori, Hiroshi Yamazaki, Frederick Peter Guengerich, Tsutomu Shimada
Preference for O-demethylation reactions in the oxidation of 2'-, 3'-, and 4'-methoxyflavones by human cytochrome P450 enzymes. Xenobiotica; the fate of foreign compounds in biological systems 50 (10) (2020)
Tomonori Miura, Makiko Shimizu, Shotaro Uehara, Manae Yoshizawa, Ayane Nakano, Mayu Yanagi, Yusuke Kamiya, Norie Murayama, Hiroshi Suemizu, Hiroshi Yamazaki
Different Hepatic Concentrations of Bromobenzene, 1,2-Dibromobenzene, and 1,4-Dibromobenzene in Humanized-Liver Mice Predicted Using Simplified Physiologically Based Pharmacokinetic Models as Putative Markers of Toxicological Potential. Chemical research in toxicology 33 (12) (2020)
Shin-Ichiro Ogawa, Makiko Shimizu, Hiroshi Yamazaki
Plasma concentrations of pemafibrate with co-administered drugs predicted by physiologically based pharmacokinetic modeling in virtual populations with renal/hepatic impairment. Xenobiotica; the fate of foreign compounds in biological systems 50 (9) (2020)
Yusuke Kamiya, Shohei Otsuka, Tomonori Miura, Manae Yoshizawa, Ayane Nakano, Miyu Iwasaki, Yui Kobayashi, Makiko Shimizu, Masato Kitajima, Fumiaki Shono, Kimito Funatsu, Hiroshi Yamazaki
Physiologically Based Pharmacokinetic Models Predicting Renal and Hepatic Concentrations of Industrial Chemicals after Virtual Oral Doses in Rats. Chemical research in toxicology 33 (7) (2020)
Akiko Toda, Makiko Shimizu, Shotaro Uehara, Tatsuro Sasaki, Tomonori Miura, Masayuki Mogi, Masahiro Utoh, Hiroshi Suemizu, Hiroshi Yamazaki
Plasma and hepatic concentrations of acetaminophen and its primary conjugates after oral administrations determined in experimental animals and humans and extrapolated by pharmacokinetic modeling. Xenobiotica; the fate of foreign compounds in biological systems 51 (3) (2020)
Yasuhiro Uno, Takahiro Mikami, Yasuko Tsukazaki, Yasuharu Nakanishi, Norie Murayama, Shinichi Ikushiro, Hideshi Tsusaki, Hiroshi Yamazaki
Genetic variants of UDP-glucuronosyltransferases 1A1, 1A6, and 1A9 in cynomolgus and rhesus macaques. Xenobiotica; the fate of foreign compounds in biological systems 51 (1) (2020)
Shin-Ichiro Ogawa, Makiko Shimizu, Hiroshi Yamazaki
Modelled plasma concentrations of pemafibrate with co-administered typical cytochrome P450 inhibitors clopidogrel, fluconazole or clarithromycin predicted by physiologically based pharmacokinetic modelling in virtual populations. Xenobiotica; the fate of foreign compounds in biological systems 50 (12) (2020)
Tomonori Miura, Shotaro Uehara, Kazuki Shigeta, Manae Yoshizawa, Yusuke Kamiya, Norie Murayama, Makiko Shimizu, Hiroshi Suemizu, Hiroshi Yamazaki
Metabolic Profiles of Tetrabromobisphenol A in Humans Extrapolated from Humanized-Liver Mouse Data Using a Simplified Physiologically Based Pharmacokinetic Model. Chemical research in toxicology 34 (2) (2020)
Koichiro Adachi, Jumpei Tuchiya, Satoru Beppu, Kei Nishiyama, Makiko Shimizu, Hiroshi Yamazaki
Pharmacokinetics of anticoagulant edoxaban in overdose in a Japanese patient transported to hospital. Journal of pharmaceutical health care and sciences 6 (2020)
Tomonori Miura, Shotaro Uehara, Sawa Mizuno, Manae Yoshizawa, Norie Murayama, Yusuke Kamiya, Makiko Shimizu, Hiroshi Suemizu, Hiroshi Yamazaki
Steady-State Human Pharmacokinetics of Monobutyl Phthalate Predicted by Physiologically Based Pharmacokinetic Modeling Using Single-Dose Data from Humanized-Liver Mice Orally Administered with Dibutyl Phthalate. Chemical research in toxicology 32 (2) (2019)
Shotaro Uehara, Norie Murayama, Hiroshi Yamazaki, Hiroshi Suemizu
Regioselective hydroxylation of an antiarrhythmic drug, propafenone, mediated by rat liver cytochrome P450 2D2 differs from that catalyzed by human P450 2D6. Xenobiotica; the fate of foreign compounds in biological systems 49 (11) (2019)
Tsuyoshi Takahashi, Yasuhiro Uno, Hiroshi Yamazaki, Toshiyuki Kume
Functional characterization for polymorphic organic anion transporting polypeptides (OATP/SLCO1B1, 1B3, 2B1) of monkeys recombinantly expressed with various OATP probes. Biopharmaceutics & drug disposition 40 (2) (2019)
Yasuhiro Uno, Hiroshi Yamazaki
Expression levels of microRNAs that are potential cytochrome P450 regulators in cynomolgus macaques. Xenobiotica; the fate of foreign compounds in biological systems 50 (7) (2019)
Hiroshi Iwata, Masatomo Goto, Norifumi Sakai, Hiroshi Suemizu, Hiroshi Yamazaki
Predictability of human pharmacokinetics of diisononyl phthalate (DINP) using chimeric mice with humanized liver. Xenobiotica; the fate of foreign compounds in biological systems 49 (11) (2019)
Shin-Ichiro Ogawa, Yoshihiko Tsunenari, Hiroyuki Kawai, Hiroshi Yamazaki
Pharmacokinetics and metabolism of pemafibrate, a novel selective peroxisome proliferator-activated receptor-alpha modulator, in rats and monkeys. Biopharmaceutics & drug disposition 40 (1) (2019)
Shin-Ichiro Ogawa, Shotaro Uehara, Yoshihiko Tsunenari, Hiroyuki Kawai, Hiroshi Suemizu, Hiroshi Yamazaki
Prediction of circulating human metabolites of pemafibrate, a novel antidyslipidemic drug, using chimeric mice with humanized liver. Xenobiotica; the fate of foreign compounds in biological systems 50 (7) (2019)
Yusuke Kamiya, Shohei Otsuka, Tomonori Miura, Hiroka Takaku, Rio Yamada, Mayuko Nakazato, Hitomi Nakamura, Sawa Mizuno, Fumiaki Shono, Kimito Funatsu, Hiroshi Yamazaki
Correction to "Plasma and Hepatic Concentrations of Chemicals after Virtual Oral Administrations Extrapolated Using Rat Plasma Data and Simple Physiologically Based Pharmacokinetic Models". Chemical research in toxicology 32 (4) (2019)
Tomonori Miura, Shotaro Uehara, Makiko Shimizu, Norie Murayama, Masahiro Utoh, Hiroshi Suemizu, Hiroshi Yamazaki
Different Roles of Human Cytochrome P450 2C9 and 3A Enzymes in Diclofenac 4'- and 5-Hydroxylations Mediated by Metabolically Inactivated Human Hepatocytes in Previously Transplanted Chimeric Mice. Chemical research in toxicology 33 (2) (2019)
Takeshi Sawada, Yoshiyuki Yamaura, Satonori Higuchi, Haruo Imawaka, Hiroshi Yamazaki
Predicting successful/unsuccessful extrapolation for in vivo total clearance of model compounds with a variety of hepatic intrinsic metabolism and protein bindings in humans from pharmacokinetic data using chimeric mice with humanised liver. Xenobiotica; the fate of foreign compounds in biological systems 50 (5) (2019)
Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki, Hiroshi Suemizu
Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes. Xenobiotica; the fate of foreign compounds in biological systems 50 (6) (2019)
Miki Ota, Makiko Shimizu, Yusuke Kamiya, Chie Emoto, Tsuyoshi Fukuda, Hiroshi Yamazaki
Adult and infant pharmacokinetic profiling of dihydrocodeine using physiologically based pharmacokinetic modeling. Biopharmaceutics & drug disposition 40 (9) (2019)
Haruna Nagayoshi, Norie Murayama, Kensaku Kakimoto, Masaki Tsujino, Shigeo Takenaka, Jun Katahira, Young-Ran Lim, Donghak Kim, Hiroshi Yamazaki, Masayuki Komori, Frederick Peter Guengerich, Tsutomu Shimada
Oxidation of Flavone, 5-Hydroxyflavone, and 5,7-Dihydroxyflavone to Mono-, Di-, and Tri-Hydroxyflavones by Human Cytochrome P450 Enzymes. Chemical research in toxicology 32 (6) (2019)
Haruna Nagayoshi, Norie Murayama, Kensaku Kakimoto, Shigeo Takenaka, Jun Katahira, Young-Ran Lim, Vitchan Kim, Donghak Kim, Hiroshi Yamazaki, Masayuki Komori, F Peter Guengerich, Tsutomu Shimada
Site-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes. Xenobiotica; the fate of foreign compounds in biological systems 49 (7) (2018)
Yasuhiro Uno, Shotaro Uehara, Norie Murayama, Hiroshi Yamazaki
Cytochrome P450 1A1, 2C9, 2C19, and 3A4 Polymorphisms Account for Interindividual Variability of Toxicological Drug Metabolism in Cynomolgus Macaques. Chemical research in toxicology 31 (12) (2018)
Yasuhiro Uno, Norie Murayama, Hiroshi Yamazaki
Molecular and Functional Characterization of N-Acetyltransferases NAT1 and NAT2 in Cynomolgus Macaque. Chemical research in toxicology 31 (11) (2018)
Takashi Koyanagi, Koji Yano, Soonih Kim, Norie Murayama, Hiroshi Yamazaki, Ikumi Tamai
In vivo hepatic clearance of lipophilic drugs predicted by in vitro uptake data into cryopreserved hepatocytes suspended in sera of rats, guinea pigs, monkeys and humans. Xenobiotica; the fate of foreign compounds in biological systems 49 (8) (2018)
Keigo Nakayama, Soichiro Ito, Masahiro Suzuki, Hiroaki Takubo, Hiroshi Yamazaki, Yukihiro Nomura
Prediction of human pharmacokinetics of typical compounds by a physiologically based method using chimeric mice with humanized liver. Xenobiotica; the fate of foreign compounds in biological systems 49 (4) (2018)
Makiko Shimizu, Hiromi Yoda, Narumi Igarashi, Miki Makino, Emi Tokuyama, Hiroshi Yamazaki
Novel variants and haplotypes of human flavin-containing monooxygenase 3 gene associated with Japanese subjects suffering from trimethylaminuria. Xenobiotica; the fate of foreign compounds in biological systems 49 (10) (2018)
Yusuke Kamiya, Shohei Otsuka, Tomonori Miura, Hiroka Takaku, Rio Yamada, Mayuko Nakazato, Hitomi Nakamura, Sawa Mizuno, Fumiaki Shono, Kimito Funatsu, Hiroshi Yamazaki
Plasma and Hepatic Concentrations of Chemicals after Virtual Oral Administrations Extrapolated Using Rat Plasma Data and Simple Physiologically Based Pharmacokinetic Models. Chemical research in toxicology 32 (1) (2018)
Yasuhiro Uno, Shotaro Uehara, Hiroshi Yamazaki
Polymorphisms of cytochrome P450 2B6 (CYP2B6) in cynomolgus and rhesus macaques. Journal of medical primatology (2018)
Chie Makino, Akiko Watanabe, Tsuneo Deguchi, Hideyuki Shiozawa, Ilona Schreck, Veronika Rozehnal, Tomoko Ishizuka, Nobuaki Watanabe, Osamu Ando, Norie Murayama, Hiroshi Yamazaki
In vivo multiple metabolic pathways for a novel G protein-coupled receptor 119 agonist DS-8500a in rats: involvement of the 1,2,4-oxadiazole ring-opening reductive reaction in livers under anaerobic conditions. Xenobiotica; the fate of foreign compounds in biological systems 49 (8) (2018)
Yusuke Kamiya, Tsutomu Yamaki, Shigehiro Omori, Masaki Uchida, Kazuo Ohtake, Mitsutoshi Kimura, Hiroshi Yamazaki, Hideshi Natsume
Improved Intranasal Retentivity and Transnasal Absorption Enhancement by PEGylated Poly-l-ornithine. Pharmaceuticals (Basel, Switzerland) 11 (1) (2018)
Hidetoshi Shimizu, Kosuke Yoshida, Tomohisa Nakada, Koki Kojima, Akihito Ogasawara, Yoshinobu Nakamaru, Hiroshi Yamazaki
Prediction of Human Distribution Volumes of Compounds in Various Elimination Phases Using Physiologically Based Pharmacokinetic Modeling and Experimental Pharmacokinetics in Animals. Drug metabolism and disposition: the biological fate of chemicals 47 (2) (2018)
Tomonori Miura, Hiroshi Suemizu, Masatomo Goto, Norifumi Sakai, Hiroshi Iwata, Makiko Shimizu, Hiroshi Yamazaki
Human urinary concentrations of monoisononyl phthalate estimated using physiologically based pharmacokinetic modeling and experimental pharmacokinetics in humanized-liver mice orally administered with diisononyl phthalate. Xenobiotica; the fate of foreign compounds in biological systems 49 (5) (2018)
Yasuhiro Uno, Norie Murayama, Masami Kato, Saki Tanaka, Tomoko Ohkoshi, Hiroshi Yamazaki
Genetic Variants of Glutathione S-Transferase GSTT1 and GSTT2 in Cynomolgus Macaques: Identification of GSTT Substrates and Functionally Relevant Alleles. Chemical research in toxicology 31 (10) (2018)
Yasuhiro Uno, Makiko Shimizu, Hiromi Yoda, Hiroshi Yamazaki
Expression and metabolic activity of flavin-containing monooxygenase 1 in cynomolgus macaque kidney. Journal of medical primatology 48 (1) (2018)
Kanami Shimura, Norie Murayama, Saki Tanaka, Shunsuke Onozeki, Hiroshi Yamazaki
Suitable albumin concentrations for enhanced drug oxidation activities mediated by human liver microsomal cytochrome P450 2C9 and other forms predicted with unbound fractions and partition/distribution coefficients of model substrates. Xenobiotica; the fate of foreign compounds in biological systems 49 (5) (2018)

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Hiroshi Yamazaki