LRWD1 expression is regulated through DNA methylation in human testicular embryonal carcinoma cells.
Jui-Hsiang HungHan-Yi ChengYung-Chieh TsaiHsien-An PanHany A OmarChien-Chih ChiuYin-Mei SuYung-Ming LinHany A OmarPublished in: Basic and clinical andrology (2021)
Thus, the regulation of LRWD1 expression is correlated with the methylation status of LRWD1 promoter, which played a significant role in the modulation of spermatogenesis, sperm motility, and vitality. Based on these results, the methylation status of LRWD1 promoter may serve as a novel molecular diagnostic marker or a therapeutic target in males' infertility.
Keyphrases
- dna methylation
- genome wide
- poor prognosis
- gene expression
- transcription factor
- endothelial cells
- binding protein
- type diabetes
- long non coding rna
- induced pluripotent stem cells
- metabolic syndrome
- adipose tissue
- pseudomonas aeruginosa
- biofilm formation
- escherichia coli
- cystic fibrosis
- staphylococcus aureus
- germ cell