Transcriptomic Profiling of MSI-H/dMMR Gastrointestinal Tumors to Identify Determinants of Responsiveness to Anti-PD-1 Therapy.

Akihito Kawazoe Akihito KawazoeToshihiro SuzukiMasahito Kawazu Toshihide UenoKazumasa TakenouchiYoshiaki NakamuraYasutoshi KubokiDaisuke KotaniTakashi KojimaHideaki Bando Saori Mishima Takeshi Kuwata Naoya Sakamoto Jun Watanabe Hiroyuki Mano Masafumi Ikeda Kohei Shitara Itraru EndoTetsuya NakatsuraTakayuki Yoshino

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

Several transcriptomic features, including CMS classification and related genes, were associated with response to PD-1 blockade in MSI-H/dMMR gastrointestinal tumors. These findings can help develop predictive biomarkers or combination immunotherapies.

Keyphrases

single cell
rna seq
machine learning
deep learning
stem cells
replacement therapy