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Excessive daytime sleepiness and epilepsy: a systematic review.

Andre S GiorelliPâmela PassosThiago CarnavalMarleide da Mota Gomes
Published in: Epilepsy research and treatment (2013)
Background. Sleep complaints are common in patients with epilepsy (PWE). Excessive daytime sleepiness (EDS) is one of the most reported complaints and its impact is still a matter of debate. Objective. Evaluate the relationship between EDS and epilepsy, with emphasis on prevalence, assessment, and causes. Methods. A systematic review on PubMed database in the last 10 years (2002 to 2012). The search returned 53 articles and 34 were considered relevant. After citation analysis, 3 more articles were included. Results. Most studies were cross-sectional and questionnaire based. 14 papers addressed EDS as the primary endpoint. 14 adult and 3 children studies used subjective and objective analysis as methodology. The number of studies increased throughout the decade, with 21 in the last 5 years. Adult studies represent almost three times the number of children studies. EDS prevalence in PWE varies from 10 to 47.5%. Prevalence was higher in developing countries. Conclusion. EDS seems to be related more frequently to undiagnosed sleep disorders than to epilepsy-related factors, and although it affects the quality of life of PWE, it can be improved by treating comorbid primary sleep disorders.
Keyphrases
  • sleep quality
  • obstructive sleep apnea
  • case control
  • cross sectional
  • risk factors
  • physical activity
  • depressive symptoms
  • young adults
  • emergency department
  • weight gain
  • body mass index
  • sleep apnea