hiPSC-Derived Cells as Models for Drug Discovery.

Published in: International journal of molecular sciences (2021)

More than 85% of pre-clinically tested drugs fail during clinical trials, which results in a long, inefficient and costly process, suggesting that animal models are often poor predictors of human biology [...].

Keyphrases

drug discovery
clinical trial
induced apoptosis
endothelial cells
cell cycle arrest
induced pluripotent stem cells
endoplasmic reticulum stress
cell death
randomized controlled trial
phase ii
drug induced
phase iii