Concurrent lipidomics and proteomics on malignant plasma cells from multiple myeloma patients: Probing the lipid metabolome.

Ahmed MohamedJoel CollinsHui JiangJeffrey MolendijkThomas StollFederico TortaMarkus R WenkRobert J BirdPaula MarltonPeter MolleeKate A MarkeyMichelle M Hill

Published in: PloS one (2020)

This study establishes the feasibility and workflow to conduct integrated lipidomics and proteomics analyses on patient-derived plasma cells. Potential lipid metabolism changes associated with MM relapse warrant further investigation.

Keyphrases

end stage renal disease
mass spectrometry
multiple myeloma
induced apoptosis
ejection fraction
newly diagnosed
chronic kidney disease
fatty acid
prognostic factors
cell cycle arrest
oxidative stress
label free
cell death
endoplasmic reticulum stress
free survival
rectal cancer