Intrahepatic CD69 + Vδ1 T cells re-circulate in the blood of patients with metastatic colorectal cancer and limit tumor progression.

Elena BruniMatteo Maria CiminoMatteo DonadonRoberta CarrieroSara TerzoliRocco PiazzaSarina RavensImmo PrinzValentina CazzettaPaolo MarzanoPaolo KunderfrancoClelia PeanoCristiana SoldaniBarbara FranceschiniFederico Simone ColomboCecilia GarlandaAlberto MantovaniGuido TorzilliJoanna MikulakDomenico Mavilio

Published in: Journal for immunotherapy of cancer (2022)

cells re-circulating at high frequencies in PB of patients with CLM limits tumor progression and represents a new important clinical tool to either predict the natural history of CLM or develop alternative therapeutic protocols of cellular therapies.

Keyphrases

metastatic colorectal cancer
poor prognosis
induced apoptosis
cell cycle arrest
heavy metals
signaling pathway
cell death
cell proliferation