A novel selective PPARα modulator, pemafibrate promotes ischemia-induced revascularization through the eNOS-dependent mechanisms.
Hiroshi KawanishiKoji OhashiHayato OgawaNaoya OtakaTomonobu TakikawaLixin FangYuta OzakiMikito TakefujiToyoaki MuroharaNoriyuki OuchiPublished in: PloS one (2020)
These data suggest that pemafibrate can promote revascularization in response to ischemia, at least in part, through direct and FGF21-mediated modulation of endothelial cell function. Thus, pemafibrate could be a potentially beneficial drug for ischemic vascular disease.
Keyphrases
- endothelial cells
- high glucose
- percutaneous coronary intervention
- coronary artery bypass grafting
- diabetic rats
- electronic health record
- big data
- insulin resistance
- coronary artery disease
- nitric oxide synthase
- ischemia reperfusion injury
- pi k akt
- nitric oxide
- type diabetes
- acute coronary syndrome
- oxidative stress
- emergency department
- adverse drug
- machine learning
- adipose tissue
- cerebral ischemia
- skeletal muscle
- fatty acid
- artificial intelligence
- cell proliferation