Association between early nutrition support and 28-day mortality in critically ill patients: the FRANS prospective nutrition cohort study.
Emmanuel PardoThomas LescotJean-Charles PreiserPablo MassanetAntoine PonsSamir JaberVincent FraipontEric LevesqueCarole IchaiLaurent PetitFabienne TamionGarry TavernyPriscilla BoizeauCorinne AlbertiJean-Michel ConstantinMarie-Pierre Bonnetnull nullPublished in: Critical care (London, England) (2023)
In this prospective cohort study, early nutrition support in the ICU was significantly associated with increased mortality at D28, particularly in younger patients with less severe disease. Compared to no early nutrition, only early enteral nutrition appeared to be associated with increased mortality. Such findings are in contrast with current guidelines on the provision of early nutrition support in the ICU and may challenge our current practices, particularly concerning patients at low nutrition risk. Trial registration ClinicalTrials.gov Identifier: NCT02599948. Retrospectively registered on November 5th 2015.
Keyphrases
- physical activity
- intensive care unit
- cardiovascular events
- end stage renal disease
- clinical trial
- risk factors
- healthcare
- magnetic resonance
- chronic kidney disease
- ejection fraction
- randomized controlled trial
- cardiovascular disease
- mechanical ventilation
- coronary artery disease
- study protocol
- magnetic resonance imaging
- patient reported outcomes
- drug induced
- extracorporeal membrane oxygenation