Milk fat globule membrane attenuates high fat diet-induced neuropathological changes in obese Ldlr-/-.Leiden mice.
Ilse A C ArnoldussenMartine C MorrisonMaximilian WiesmannJanna A van DiepenNicole WormsMarijke VoskuilenVivienne VerweijBram GeenenNatàlia Pujol GualdoLonneke van der LogtGabriele GrossRobert KleemannAmanda Johanne KiliaanPublished in: International journal of obesity (2005) (2021)
We showed that supplementation with WPC high in MFGM components beneficially contributed to hippocampal-dependent spatial memory, functional connectivity in the hippocampus and anti-inflammatory processes in HFD-induced obesity in rodents. Current knowledge regarding exact biological mechanisms underlying these effects should be addressed in future studies.
Keyphrases
- high fat diet induced
- functional connectivity
- insulin resistance
- resting state
- adipose tissue
- high fat diet
- anti inflammatory
- metabolic syndrome
- cerebral ischemia
- high glucose
- type diabetes
- healthcare
- diabetic rats
- weight loss
- skeletal muscle
- current status
- obese patients
- drug induced
- cognitive impairment
- endothelial cells
- bariatric surgery
- brain injury
- fatty acid
- molecular dynamics