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Mass-cytometry-based quantitation of global histone post-translational modifications at single-cell resolution across peripheral immune cells in IBD.

Lawrence BaiDenis DermadiLaurynas KalesinskasMai DvorakSarah E ChangAnanthakrishnan GanesanSamuel J S RubinAlex KuoPeggie CheungMichele DonatoPaul J UtzAida HabtezionPurvesh Khatri
Published in: Journal of Crohn's & colitis (2022)
We describe the first systems-level quantification of histone modifications across immune cells from IBD patients at a single-cell resolution revealing the increased epigenetic heterogeneity that is not possible with traditional ChIP-seq profiling. Our data open new directions in investigating the association between histone modifications and IBD pathology using other epigenomic tools.
Keyphrases
  • single cell
  • dna methylation
  • rna seq
  • high throughput
  • ulcerative colitis
  • genome wide
  • single molecule
  • gene expression
  • mass spectrometry
  • minimally invasive
  • ms ms
  • big data
  • high performance liquid chromatography