Convergence of YAP/TAZ, TEAD and TP63 activity is associated with bronchial premalignant severity and progression.
Boting NingAndrew M Tilston-LunelJustice SimonettiJulia Hicks-BerthetAdeline MatschulatRoxana PfefferkornAvrum SpiraMatthew EdwardsSarah MazzilliMarc E LenburgJennifer E BeaneXaralabos VarelasPublished in: Journal of experimental & clinical cancer research : CR (2023)
Our study identifies important gene regulatory functions for YAP/TAZ-TEAD-TP63 in the early stages of lung cancer development, which notably includes immune-suppressive roles, and suggest that an assessment of the activity of this transcriptional complex may offer a means to identify immune evasive bronchial PMLs and serve as a potential therapeutic target.