A longitudinal assessment of trial protocols approved by research ethics committees: The Adherance to SPIrit REcommendations in the UK (ASPIRE-UK) study.
Benjamin SpeichAyodele OdutayoNicholas PeckhamAlexander OomsJamie R StokesRamon SaccilottoDmitry GryaznovBelinda von NiederhäusernBethan CopseyDouglas G AltmanMatthias BrielSally HopewellPublished in: Trials (2022)
The adherence to SPIRIT guidelines has improved in the UK from 2012 to 2016 but remains on a modest level, especially for non-industry-sponsored RCTs.