Cost-Effectiveness Analysis for Therapy Sequence in Advanced Cancer: A Microsimulation Approach with Application to Metastatic Prostate Cancer.

Elizabeth A Handorf J Robert BeckAndres CorreaChethan RamamurthyDaniel M Geynisman

Published in: Medical decision making : an international journal of the Society for Medical Decision Making (2023)

We developed a discrete-time state transition model for studying therapy sequence in advanced cancers.Results are sensitive to dependence within patients.A calibration approach can introduce dependence across lines of therapy and closely match simulation outcomes to target trial outcomes.

Keyphrases

prostate cancer
advanced cancer
end stage renal disease
palliative care
squamous cell carcinoma
ejection fraction
clinical trial
chronic kidney disease
study protocol
radical prostatectomy
peritoneal dialysis
patient reported outcomes
skeletal muscle