Gut Microbiota Mediates the Susceptibility of Mice to Sepsis-Associated Encephalopathy by Butyric Acid.

Huidan ZhangJing XuQingrui WuHeng FangXin ShaoXin OuyangZhimei HeYiyu DengChun-Bo Chen

Published in: Journal of inflammation research (2022)

Our findings indicate a crucial role of gut microbiota in the susceptibility to SAE. Butyrate, a metabolite of intestinal microbiota, may have a neuroprotective effect in the process of sepsis by GPR109A/Nrf2/HO-1 pathway.

Keyphrases

septic shock
acute kidney injury
intensive care unit
early onset
fatty acid
type diabetes
cell proliferation
skeletal muscle
blood brain barrier