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Dyslipidaemia and statin use in individuals aged 10 to <40 years in the T1D Exchange clinic registry.

Sarah K LyonsClaire T BoyleDaniel J DeSalvoMichael R RickelsLauren K Wood HeickmanKellee M MillerNicole C FosterMark A Clementsnull null
Published in: Diabetes, obesity & metabolism (2018)
For individuals aged 10 to <40 years with type 1 diabetes and dyslipidaemia, US national guidelines recommend consideration of statin therapy based on age, low-density lipoprotein cholesterol (LDL-C) level and other cardiovascular risk factors. We evaluated dyslipidaemia prevalence, statin therapy use, and associations between not meeting target LDL-C [<100 mg/dL (<5.55 mmol/L)] and other cardiovascular disease (CVD) risk factors in individuals aged 10 to <40 years in the T1D Exchange clinic registry. In 7223 participants, statin use was 2% in 10 to <18 year olds, 4% in 18 to <25 year olds, and 21% in 25 to <40 year olds. Individuals not on statin therapy with LDL-C above target were more likely to have ≥1 additional CVD risk factor(s) than those with LDL-C in the target range for all age groups (all P < 0.01). While most individuals not on statin therapy had LDL-C in the target range, those who did not were more likely to have ≥1 additional CVD risk factor(s), and therefore longitudinal study of lipid levels and statin use is needed to see if treatment of dyslipidaemia to target LDL-C levels may lower the risk of future CVD in individuals aged 10 to <40 years with type 1 diabetes.
Keyphrases
  • low density lipoprotein
  • cardiovascular disease
  • risk factors
  • cardiovascular risk factors
  • coronary artery disease
  • primary care
  • cardiovascular events
  • type diabetes
  • metabolic syndrome
  • fatty acid
  • clinical practice