Striatal Dopamine Loss in Early Parkinson's Disease: Systematic Review and Novel Analysis of Dopamine Transporter Imaging.

Nicholas Yew Wei HengNaveed MalekMichael A LawtonAnahita NodehiVanessa PitzKatherine A GrossetYoav Ben-ShlomoDonald G Grosset

Published in: Movement disorders clinical practice (2023)

Loss of striatal DaT activity in early PD is less at 35-45%, rather than the 50-80% striatal dopamine loss estimated to be present at the time of symptom onset, based on backwards extrapolation from autopsy studies.

Keyphrases

systematic review
parkinson disease
uric acid
functional connectivity
high resolution
prefrontal cortex
randomized controlled trial
metabolic syndrome