Exercise reduces systemic immune inflammation index (SII) in childhood cancer patients.
Matteo WinkerSandra StösselMarie Astrid NeuNadine LehmannKhalifa El MalkiClaudia ParetNiklas JoistenWilhelm BlochPhilipp ZimmerJörg FaberPublished in: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer (2021)
While exercise and physical activity have been suggested to reduce mortality and symptoms in cancer, knowledge on these associations in patients with childhood cancer (CCPs) is sparse. Anti-inflammatory properties of exercise might mediate these beneficial effects. We investigated the influence of exercise on the inflammation markers neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic-immune-inflammation index (SII) and associations to patient-reported-outcomes in CCPs in a randomized-controlled trial. Results show associations between inflammation markers and patient-reported outcomes. Compared to the control group, SII was significantly reduced following exercise (p=0.036). Anti-inflammatory effects of exercise are also present in CCPs and may underlie exercise-induced benefits on symptoms. Clinical Trial Registration Number: NCT02612025.
Keyphrases
- physical activity
- patient reported outcomes
- high intensity
- oxidative stress
- childhood cancer
- anti inflammatory
- clinical trial
- resistance training
- healthcare
- young adults
- squamous cell carcinoma
- type diabetes
- body mass index
- cardiovascular events
- randomized controlled trial
- body composition
- open label
- papillary thyroid
- phase ii
- squamous cell
- double blind