Impact of fatty acid binding protein 5-deficiency on COPD exacerbations and cigarette smoke-induced inflammatory response to bacterial infection.
Deviyani M RaoDella T PhanMichelle J ChooMichael R WeaverRebecca E Oberley-DeeganRussell P BowlerFabienne GallyPublished in: Clinical and translational medicine (2019)
These findings support a model in which CS-induced FABP5 inhibition contributes to increased inflammation in COPD exacerbations. It is interesting to speculate that the increased inflammation is a result of decreased PPARγ activity.