Serum neurofilament light chain concentration in a phase 1/2 trial of autologous mesenchymal stem cell transplantation.
Laura E BaldassariSarah Marie PlanchonRobert A BermelKunio NakamuraElizabeth FisherJenny FengKen E SakaieDaniel OntanedaJeffrey A CohenPublished in: Multiple sclerosis journal - experimental, translational and clinical (2019)
Serum neurofilament light chain concentration correlated with magnetic resonance imaging measures of disease activity cross sectionally and longitudinally, and was stable in patients without disease activity. There was no clear treatment effect of mesenchymal stem cell transplantation on serum neurofilament light chain concentration.
Keyphrases
- stem cell transplantation
- disease activity
- systemic lupus erythematosus
- rheumatoid arthritis
- high dose
- rheumatoid arthritis patients
- ankylosing spondylitis
- magnetic resonance imaging
- cerebrospinal fluid
- bone marrow
- juvenile idiopathic arthritis
- stem cells
- end stage renal disease
- computed tomography
- low dose
- magnetic resonance
- contrast enhanced
- combination therapy
- platelet rich plasma