lncRNA ZEB2-AS1: A promising biomarker in human cancers.
Zarei MahboobehMousavi PegahSadri FatemehKarimi ElhamAzari HaniehRafat MiladMohammad ShekariPublished in: IUBMB life (2020)
Long non-coding RNAs (lncRNAs) are one of the ncRNAs that transcript with length more than 200 nt that are not translated into protein. Studies have shown that lncRNAs have regulatory function in human disease especially cancers. lncRNA dysfunction causes altered cellular behavior including proliferation, invasion, and migration, and also it can inhibit apoptosis. Long non-coding zinc finger E-box binding homeobox 2 antisense RNA1 (lnZEB2-AS1) is one of the lncRNAs that plays the oncogenic role in different cancers. Dysregulation of lncZEB2-AS1 can lead to tumorigenesis and cancer progression. lncZEB2-AS1 may be introduced as a diagnostic marker or therapeutic target for human cancers. In this review, we describe briefly the mechanism of ZEB2-AS1 in cells and its function in cancer progression.
Keyphrases
- long non coding rna
- endothelial cells
- transcription factor
- induced pluripotent stem cells
- papillary thyroid
- oxidative stress
- cell cycle arrest
- epithelial mesenchymal transition
- pluripotent stem cells
- induced apoptosis
- childhood cancer
- endoplasmic reticulum stress
- cell death
- squamous cell
- network analysis
- young adults
- amino acid
- nucleic acid