Adequacy of Samples Obtained by Endobronchial Ultrasound with Transbronchial Needle Aspiration for Molecular Analysis in Patients with Non-Small Cell Lung Cancer. Systematic Review and Meta-Analysis.
Gonzalo LabarcaErik FolchMichael JantzHiren J MehtaAdnan MajidSebastian Fernandez-BussyPublished in: Annals of the American Thoracic Society (2019)
EBUS-TBNA has a high yield for molecular analysis of both EGFR and ALK mutations. However, the suitability of TBNA samples for next-generation sequencing is uncertain and should be explored in further studies. Clinical trial registered with PROSPERO (CRD42017080008).
Keyphrases
- ultrasound guided
- clinical trial
- fine needle aspiration
- small cell lung cancer
- epidermal growth factor receptor
- copy number
- tyrosine kinase
- advanced non small cell lung cancer
- magnetic resonance imaging
- phase ii
- randomized controlled trial
- double blind
- gene expression
- single molecule
- dna methylation
- computed tomography
- circulating tumor