FujiLAM for the diagnosis of childhood tuberculosis: a systematic review.
Laura OlbrichNisreen KhambatiElse Margreet BijkerMorten RuhwaldNobert HeinrichRinn SongPublished in: BMJ paediatrics open (2022)
The high specificity of FujiLAM demonstrates its potential as a point-of-care (POC) rule-in test for diagnosing paediatric TB. As an instrument-free POC test that uses an easy-to-obtain specimen, FujiLAM could significantly improve TB diagnosis in children in low-resource settings, however the small number of studies available highlight that further data are needed. Key priorities to be addressed in forthcoming paediatric evaluations include prospective head-to-head comparisons with AlereLAM using fresh specimens, specific subgroup analysis in CLHIV and extrapulmonary disease and studies in different geographical locations.CRD42021270761.
Keyphrases
- mycobacterium tuberculosis
- intensive care unit
- emergency department
- case control
- optic nerve
- young adults
- electronic health record
- pulmonary tuberculosis
- big data
- hiv aids
- clinical trial
- randomized controlled trial
- childhood cancer
- human immunodeficiency virus
- hepatitis c virus
- adverse drug
- antiretroviral therapy
- ultrasound guided