Recent Advancements in Nanomedicine Based Lipid Metabolism for Tumor lmmunotherapy.

Therapy on lipid metabolism is emerging as a groundbreaking cancer treatment, offering the unprecedented opportunity to effectively treat and in several cases. Tumorigenesis is inextricably linked to lipid metabolism. In this regard, the features of lipid metabolism include lipid synthesis, decomposition, metabolism and lipid storage and mobilization from intracellular lipid droplets. Most importantly, the regulation of lipid metabolism is central to the appropriate immune response of tumor cells, and ultimately to exert the immune efforts to realize the perspective of many anti-tumor effects. Different cancers and immune cells have different dependence on lipid metabolism, playing an pivotal role in differentiation and function of immune cells. However, what lies before the immunotherapy targeting lipid metabolism is side effects of systemic toxicity and defects of individual drugs, which strongly highlights that nanodelivery strategy is a magnet for it to enhance drug efficiency, reduce drug toxicity and improve application deficiencies. This review will firstly focus on emerging research progress of lipid metabolic reprogramming mechanism, and then explore the complex role of lipid metabolism in the tumor cells including the effect on immune cells and their nano-preparations of monotherapy and multiple therapies used in combination, in a shift away from conventional cancer research. Graphical Abstract .