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Systematic review: predictive biomarkers of therapeutic response in inflammatory bowel disease-personalised medicine in its infancy.

Toer W StevensMijntje MatheeuwsenMaria H LönnkvistClaire E ParkerManon E WildenbergKrisztina B GecseGeert R D'Haens
Published in: Alimentary pharmacology & therapeutics (2018)
The search for predictive biomarkers is still in its infancy and current evidence is limited. Future research efforts should take into account the high patient heterogeneity within prospective trials with objective response assessment. Predictive models will most likely comprise a combination of several molecular markers from integrated omics-levels and clinical characteristics.
Keyphrases
  • systematic review
  • single cell
  • weight gain
  • meta analyses
  • randomized controlled trial
  • quality improvement
  • single molecule
  • clinical evaluation