The tumor microbiome as a predictor of outcomes in patients with metastatic melanoma treated with immune checkpoint inhibitors.
Caroline E DravillasSamuel S ColemanRebecca HoydLouis DenkoCarlos H F ChanMichelle L ChurchmanNicholas C DenkoRebecca D DoddIslam El JilanySheetal HardikarMarium HusainAlexandra P IkeguchiNing JinQin MaMartin D McCarterAfaf E G OsmanLary A RobinsonEric A SingerGabriel TinocoCornelia M UlrichYousef ZakhariaDaniel J SpakowiczAhmad A TarhiniAik Choon TanPublished in: bioRxiv : the preprint server for biology (2023)
We analyzed the tumor microbiome and interactions with genes and pathways in metastatic melanoma treated with immunotherapy, and identified several microbes associated with immunotherapy response and immune-related gene expression signatures. Machine learning models that combined microbe abundances and gene expression outperformed models using either dataset alone in predicting immunotherapy responses.