Rituximab Attenuated Lipopolysaccharide-Induced Oxidative Cytotoxicity, Apoptosis, and Inflammation in the Human Retina Cells via Modulating the TRPM2 Signaling Pathways.
Hatice DaldalMustafa NazıroğluPublished in: Ocular immunology and inflammation (2022)
The LPS-induced mitROS, inflammatory cytokine, and apoptosis levels were modulated via TRPM2 inhibition in the human retinal epithelial cells by the RTX treatment. The RTX may be considered as a new therapeutic approach to LPS-induced human retinal epithelial cell injury.
Keyphrases
- lps induced
- inflammatory response
- lipopolysaccharide induced
- endothelial cells
- oxidative stress
- cell cycle arrest
- signaling pathway
- induced pluripotent stem cells
- induced apoptosis
- diabetic retinopathy
- cell death
- endoplasmic reticulum stress
- optical coherence tomography
- pluripotent stem cells
- optic nerve
- diffuse large b cell lymphoma
- smoking cessation
- hodgkin lymphoma