Post-Transcriptional Modifications of RNA as Regulators of Apoptosis in Glioblastoma.
Anton S DomeMayya Alexandrovna DymovaVladimir RichterGrigory A StepanovPublished in: International journal of molecular sciences (2022)
This review is devoted to changes in the post-transcriptional maturation of RNA in human glioblastoma cells, which leads to disruption of the normal course of apoptosis in them. The review thoroughly highlights the latest information on both post-transcriptional modifications of certain regulatory RNAs, associated with the process of apoptosis, presents data on the features of apoptosis in glioblastoma cells, and shows the relationship between regulatory RNAs and the apoptosis in tumor cells. In conclusion, potential target candidates are presented that are necessary for the development of new drugs for the treatment of glioblastoma.
Keyphrases
- cell cycle arrest
- cell death
- endoplasmic reticulum stress
- induced apoptosis
- pi k akt
- oxidative stress
- transcription factor
- gene expression
- endothelial cells
- signaling pathway
- healthcare
- risk assessment
- climate change
- big data
- deep learning
- social media
- machine learning
- smoking cessation
- combination therapy
- heat stress
- data analysis
- pluripotent stem cells
- health information