Integrated Bioinformatic Analysis of SARS-CoV-2 Infection Related Genes ACE2, BSG and TMPRSS2 in Aerodigestive Cancers.

Chaobin He Xin HuaShuxin SunShao-Long LiJun WangXin Huang

Published in: Journal of inflammation research (2021)

SARS-CoV-2 entry genes were highly expressed in CRC, and we reported for the first time higher expression of ACE2 in lung metastases from CRC than in normal lung, indicating that these patients may be more susceptible to extrapulmonary or pulmonary SARS-CoV-2 infection. Since our study is a bioinformatic analysis, further experimental evidences and clinical data are urgently needed.

Keyphrases

sars cov
respiratory syndrome coronavirus
end stage renal disease
ejection fraction
chronic kidney disease
poor prognosis
angiotensin converting enzyme
pulmonary hypertension
genome wide
patient reported outcomes
binding protein
young adults
long non coding rna
data analysis