Antihypertensive Drugs for the Prevention of Atrial Fibrillation: A Drug Target Mendelian Randomization Study.
Sven GeurtsMartijn J TillyZuolin LuBruno H C StrickerJaap W DeckersNatasja M S De GrootClint T MillerMohammad Arfan IkramMaryam KavousiPublished in: Hypertension (Dallas, Tex. : 1979) (2024)
Our results indicated that lowering systolic blood pressure via protein targets of various antihypertensive drugs seems promising for AF prevention. Our findings inform future clinical trials and have implications for repurposing antihypertensive drugs for AF prevention.
Keyphrases
- blood pressure
- atrial fibrillation
- hypertensive patients
- clinical trial
- heart rate
- heart failure
- left atrial
- randomized controlled trial
- blood glucose
- left ventricular
- oral anticoagulants
- left atrial appendage
- percutaneous coronary intervention
- emergency department
- direct oral anticoagulants
- acute coronary syndrome
- adipose tissue
- skeletal muscle
- metabolic syndrome
- insulin resistance
- adverse drug
- binding protein