Exosomes Derived from Human Urine-Derived Stem Cells Inhibit Intervertebral Disc Degeneration by Ameliorating Endoplasmic Reticulum Stress.
HongFei XiangWeiLiang SuXiaolin WuWujun ChenWenBin CongShuai YangChang LiuChenSheng QiuShang-You YangYan WangGuoQing ZhangZhu GuoDong-Ming XingBo-Hua ChenPublished in: Oxidative medicine and cellular longevity (2020)
Through the AKT and ERK signaling pathways, USCs-exos significantly inhibit ER stress-induced cell apoptosis and IDD under pressure conditions. It is, therefore, a viable therapeutic strategy.
Keyphrases
- stress induced
- endoplasmic reticulum stress
- signaling pathway
- stem cells
- induced apoptosis
- cell proliferation
- pi k akt
- endothelial cells
- epithelial mesenchymal transition
- mesenchymal stem cells
- induced pluripotent stem cells
- pluripotent stem cells
- cell therapy
- oxidative stress
- bone marrow
- breast cancer cells
- endoplasmic reticulum